Health Studies on Whole Grains

Rye Bread Replaces Laxatives

In a recent Finnish study, rye bread proved more effective than laxatives in reducing mild constipation and improving colonic metabolism, without causing adverse gastrointestinal effects. Researchers at the University of Helsinki randomly assigned 51 constipated adults to five groups that consumed: rye bread, cultured buttermilk, rye bread + buttermilk, white wheat bread, and laxatives (as usual for participant). The rye bread proved most effective, cutting transit time 41% compared to laxatives.
Journal of Nutrition, January 2010; epub ahead of print

Oats May Boost Nutrition Profile of Gluten-free Diets

Two recent studies out of Scandinavia show that adding oats to a gluten-free diet may enhance the nutritional values of the diets, particularly for vitamins and minerals, as well as increasing antioxidant levels.  Researchers asked 13 men and 18 women with Celiac disease to follow a gluten-free diet with the addition of kilned (stabilized) or unkilned oats.  After six months, the addition of stabilized oats resulted in an increased intake of vitamin B1 and magnesium, while the unkilned oats increased intakes of magnesium and zinc.  In the second study from Scandinavia, the addition of gluten-free oats allowed people on gluten-free diets to achieve their recommended daily intakes of fiber, as well as increasing levels of a particular antioxidant called bilirubin, which helps the body eliminate free radicals as well as protect the brain from oxidative damage.
European Journal of Clinical Nutrition, January 2010; 64:62-67, DOI:10.1038/ejcn.2009.113 and
The European e-Journal of Clinical Nutrition and Metabolism, December 2009; e315-e320

High-Carb: Better Moods than Low Carb

Researchers in Australia studying 106 overweight and obese adults put 55 of them on a very low-carb, high-fat diet, and 51 on a very low-fat, high-carb diet. After a year, weight loss in both groups was about the same (13.7 kg or 30.2 lbs). But, while both groups reported improved mood after the first 8 weeks, after that only the higher-carb group maintained their good mood; the low-carb group was more angry, depressed, and confused after a year on the Atkins-like diet. Researchers suggested a link to better serotonin synthesis with the higher-carb diet, or perhaps to "withdrawal symptoms" in Western-diet environment replete with breads and cereals.
Archives of Internal Medicine, November 2009; 169(20):1873-1880

Lower Abdominal Fat with Higher Whole Grain Intake

Nicola McKeown and a team of Tufts researchers studied 434 older (age 60 to 80) adults, comparing their diet to their body fat and abdominal fat composition. No significant association was found between body composition and intake of total fiber or vegetable and fruit fiber. Whole grain intake and cereal fiber intake, however, correlated strongly with lower BMI, lower total percent body fat and lower abdominal ("trunk fat") mass in older adults.
Journal of Nutrition, October 2009; 139(10);1950-1955. DOI:10.3945/jn.108.103762

"Prudent" Diet May Reduce Breast Cancer Risk

Increasing attention is being paid to overall dietary patterns and their relationship to health, rather than single nutrients or foods. In one such study of more than 50,000 African-American women, researchers led by Tanya Agurs-Collins of the U.S. National Cancer Institute found that eating a "prudent diet" (high in fruits, vegetables, fish and whole grains) rather than a "Western diet" (more refined grains, processed meats, sweets) cut the risk of breast cancer. The findings were especially strong for thinner, younger women and for certain types of breast cancer.
American Journal of Clinical Nutrition, September 2009; vol 90, No. 3, 621-628. DOI:10.3945/ajcn.2009.27666 

Feel Fuller Longer With Rye

In a new study published by the Nutrition Journal, Swedish researchers report that eating rye at breakfast suppresses appetite over the next few hours much better than wheat. Attributing this to the power of rye fiber, particularly in rye bran, the researchers fed sixteen volunteers breakfasts including bread containing varying levels of rye, but all with the same caloric value. Those who ate the bread with the highest levels of rye fiber reported a lowered desire to eat in the hours between breakfast and lunch, while those who ate bread made with wheat flour felt hungrier earlier. Researchers concluded that the consumption of rye, whether through pure rye bran or sifted rye flour, created a feeling of satiety unmatched by wheat.
Nutrition Journal, August 28, 2009; 8:39. DOI:10.1186/1475-2891-8-39

Higher Carbs, Less Risk of Overweight

Canadian researchers examined the diets of 4,451 healthy free-living Canadians and found that those consuming less than 47% of their calories as carbohydrates were more likely to be overweight or obese. Lowest risk of overweight, according to the researchers, may be obtained by consuming 47% to 64% of calories as carbohydrates.
Journal of the American Dietetic Association, July 2009; vol 109, issue 7, 1165-1172

More Whole Grains, Less Hypertension

Researchers at Brigham and Women's Hospital and the Harvard Medical School followed 31,784 men in the Health Professionals Follow-up Study for 18 years, and found that about one-third developed hypertension, or high blood pressure. The researchers found that men who ate the most whole grains had a 19% reduced risk of developing high blood pressure. Those with higher bran consumption had a 15% reduced risk of hypertension, leading researchers to conclude that bran may play an important role in the preventiono of hypertension.
American Journal of Clinical Nutrition, July 1, 2009. DOI:10.3945/ajcn.2009.27460

Whole Grains Cut Cholesterol

Italy's National Research Council (CNR) just published a study showing that healthy middle-age adults lowered total cholesterol by 4.3% and LDL ("bad") cholesterol by 4.9%, by eating whole grains instead of refined grains. The crossover study randomly assigned the 15 subjects to consume either refined or whole grains, in two equal-calorie diets. After three weeks, both groups took a "washout" break for two weeks, then switched diets. Although researchers reported no changes in blood or fat metabolism, hormones associated with insulin levels, compounds linked to immune response, magnesium levels, or CRP (a marker of inflation) with either diet, the subjects' fasting cholesterol levels definitely improved on the whole grain diet.
Nutrition, Metabolism, and Cardiovascular Disease, online June 9, 2009. DOI:10.1016/j.numecd.2009.03.025

Whole Grain Cereal for Muscle Recovery

Athletes often choose sports drinks to aid with muscle recovery after endurance exercise. A recent study by Lynne Kammer and her team at the University of Texas compared the effects of ingesting a popular carbohydrate-electrolyte sports drink to those from eating whole grain cereal with low-fat milk, and concluded that the whole grain cereal and milk choice was equal to the sports drink in initiating post-exercise muscle recovery.
Journal of the International Society of Sports Nutrition, May 2009; 6:11. DOI:10.1186/1550-2783-6-11 

Whole Grains Lower Risk of Colon Cancer

Researchers in Brazil conducted a meta-analysis of 11 cohort studies including 1,719,590 participants, who were followed from 6 to 16 years. Their overall conclusion was that "consumption of whole grains was inversely associated with the risk of developing colorectal cancer."
International Journal of Food Sciences and Nutrition, March 2009; 21:1-13

Lignans Associated with Weight Control 

In Quebec, a University of Laval team led by André Tchernof, studied 115 post-menopausal women and found that those with markers showing more consumption of plant lignans had, on average, a BMI 4km/m2 lower than women with the lowest levels of the markers. They also had better blood sugar control and lower blood pressure. Lignans are found in whole grains, as well as in fruits and vegetables.
British Journal of Nutrition, February 2009. Online First View, DOI:10.1017/S0007114508162092

Fermented Dough Higher in Antioxidants

Nutrition and food scientists at the University of Maryland, led by Professor Liangli Yu, studied the antioxidant activity in pizza doughs fermented for different periods and cooked at different temperatures. They found that dough left to ferment for 48 hours had a 130 percent rise in a major wheat antioxidant – and that cooking the pizza for just 7 minutes at 288°C (550° F) resulted in a pie that had the highest oxygen radical absorbing and scavenging capacities.
Journal of Agricultural and Food Chemistry, 2009. DOI:10.1021/jf802083x

Whole Grains and Fruits blunt diabetes' impact

Soluble fibers from whole grains and fruits may reduce the risk of metabolic syndrome in people with Type 2 diabetes. That's the finding of T Steemburgo and a team of researchers in Brazil. Their cross-sectional study of 214 patients seems to indicate that greater consumption of fruits and vegetables may blunt some of the additional risks associated with diabetes.
European Journal of Clinical Nutrition, January 2009; 63, 127–133

Whole Grains and weight control

A team of Dutch researchers led by LPL van de Vijver studied 2078 men and 2159 women aged 55-69 years, and found that higher whole grain consumption was associated with lower BMI and a reduced risk of overweight and obesity. For every additional gram of whole grain consumption, men's risk dropped 10% and women's risk dropped 4%.
European Journal of Clinical Nutrition, January 2009; 63, 31–38

Whole Grains Lower Heart Failure Risk

Whole grain consumption lowers heart failure risk, while eggs and high-fat dairy raise risks. That's the finding of researchers from the University of Minnesota and the University of North Carolina, who followed more than 14,000 people for over 13 years. "It would be prudent to recommend that those at high risk of HF increase their intake of whole grains and reduce intake of high-fat dairy and eggs," said lead researcher Jennifer Nettleton, PhD.
Journal of the American Dietetic Association, November 2008; vol 108(11)

Western Diet Linked with Greater Mortality

After following 72, 113 women for almost twenty years, researchers at the Harvard School of Public Health concluded that eating a "prudent" diet rich in vegetables, fruits, legumes, whole grains, fish and poultry may reduce the risk for cardiovascular disease and for overall mortality. The study divided the women into two groups, those eating the "prudent" diet and those consuming a typical "Western" diet with high levels of red meat, processed meat, refined grains, french fries, and sweet or desserts.
Circulation, July 15, 2008; 118(3):230-7. Epublished June 23, 2008.

Dietary Factors reduce Diabetes Risk

The Multi-Ethnic Study of Atherosclerosis (MESA) being carried out by researchers around the U.S. and in Norway, has found that eating a "low risk food pattern" including more whole grains, fruits, green leafy vegetables, low-fat diary, and nuts/seeds, was associated with a 15% lower diabetes risk. Researcher Jennifer Nettleton, PhD, stressed that the interplay of a variety of healthy foods likely contributes to the reduced risk.
Diabetes Care, June 10, 2008

Whole Grains may help cut Acne

Australian researchers led by Neil Mann recruited 50 young males (age 15-25) with mild to moderate acne for a twelve-week study of the relationship between diet and acne. Half the group ate a typical Western diet, while the other half ate lean meat, poultry, fish, fruits, vegetables and substituted whole grain bread, cereals and rice for refined foods. After twelve weeks, the acne of the group eating more protein and whole grains "improved dramatically, by more than fifty percent."
Journal of Dermatological Science, April 2008; 50(1):41-52. Epublished January 4, 2008.

Whole Grain offers pre-biotic benefits

A double-blind, randomized, cross-over study at the University of Reading, UK, divided 31 healthy adults into two groups. Half the volunteers ate 48g of whole grain cereal daily; the other half ate the same amount of wheat bran cereal daily for three weeks. After a two-week washout on normal diets, the groups were reversed for a second period of three weeks. The study concluded that whole grain cereal promoted increases in bifidobacteria and lactobacillus, while the bran cereal did not.
British Journal of Nutrition, January 2008; vol 99(1):110-20. Epublished August 29, 2007.

Whole Grains Reduce Weight, Cut CVD Risk

In a clinical study conducted at Penn State, researchers put 50 obese adults on a reduced calorie diet for 12 weeks, during which time half the group was asked to eat all their grains as whole grains, and the other half was advised to avoid whole-grain foods. Body weight, waist circumference and percentage body fat decreased significantly in both groups, but the whole grain group saw a signicantly greater decrease in abdominal fat, and a 38% decrease in C-reactive protein (CRP), an inflammatory marker for cardiovascular disease.
American Journal of Clinical Nutrition, January 2008; vol 87(1): 79-80

Chronic Disease risks reduced with whole grain

A team of scientists in Boston and Baltimore led by PK Newby studied data from the Baltimore Longitudinal Study of Aging, and found that seniors consuming the most whole grain had lower body mass index (BMI) and weight, and smaller waist circumference. More whole grain consumption was also associated wtih lower total cholesterol, lower LDL cholesterol and improved glucose response.
American Journal of Clinical Nutrition, December 2007; vol 86(6): 1745-1753

Higher Whole Grain Intake Associated with Lower BMI

UK researchers Janice Harland and Lynne Garton pooled data from fifteen studies on whole grain intake and BMI or adiposity, and found thatin 119,829 male and female subjects age 13 or older, a higher intake of whole grains (about three servings per day) was associated with lower BMI and less central adiposity (abdominal fat).
Public Health Nutrition, November 16, 2007; 1-10. Epublished ahead of print.

Pancreatic Cancer Risk and Whole Grains

Pancreatic cancer is the most fatal cancer in the U.S., but eating two servings or more of whole grains daily may cut the risk of this swift and deadly killer by up to 40%. That was the finding of researchers at UC San Francisco led by June Chan, who compared diets of 532 pancreatic cancer patients with 1,701 people not suffering from the disease.
The American Journal of Epidemiology, November 2007; 166(10):1174-1185

Limiting Refined Carbs reduces risk of Macular Degeneration

3977 participants in the Age-Related Eye Disease Study were followed for 8 years by Chung-Jung Chiu and a team at Tufts University, who tracked the glycemic index of their diets and the development of age-related macular degeneration (AMD). The scientists concluded that seniors at risk of AMD may "benefit from consuming a smaller amount of refined carbohydrates."
American Journal of Clinical Nutrition, October 2007; vol 86(4):1210-8

Whole Grain Cereal for Healthier Hearts

After following 21,376 male physicians for almost 20 years, Luc Djoussé and J. Michael Gaziano at Harvard found that those eating two to six servings of whole grain cereal a week reduced their risk of heart failure 22%, while those eating whole grains daily reduced risk by 28%. For this study, cereals with at least 25% whole grain or bran by weight were classified as whole grain.
Archives of Internal Medicine, October 2007; 167: 2080-2085

Whole Grains Reduce Hypertension Risk

Researchers at Harvard studied nearly 30,000 enrolled in the Women’s Health Study. Lu Wang’s team found that, over ten years, those who ate the most whole grains had an 11% lower chance of developing high blood pressure.
American Journal of Clinical Nutrition, August 2007; vol 86(2):472-9

Two Whole Grain Servings Reduce Diabetes Risk

Also at the Harvard School of Public Health, researchers led by JS de Munter pooled data from six cohort studies including 286,125 participants, and found that a two-servings a day increment in whole grain consumption was associated with a 21% decrease in risk of type 2 diabetes.
PLoS Medicine, August 2007; 28;4(8):e261

Whole Grain and Healthier Carotid Arteries

A study by Philip Mellen at Wake Forest University and colleagues measured atherosclerosis of the common carotid artery, and its progression over five years. Mellen's team found that, among the 1178 men and women in the study, those who ate more whole grains had less unhealthy artherosclerotic thickening of the common carotid artery.
American Journal of Clinical Nutrition, June 2007; vol 85(6):1495-1502

Whole Grains Reduce Diabetes Risk in 40,000 Women

Dr. Rob van Dam and colleagues at the Harvard School of Public Health studied over 40,000 African-American women over eight years, and found that eating more whole-grains and low-fat dairy foods reduced the likelihood of developing type 2 diabetes.
Diabetes Care, July 2007; 30(7):1753-7

Whole Grains Reduce Inflammatory Disease Risk

That habitual whole grain consumption reduces the risk of both cardiovascular disease and diabetes has been well documented. Now, a recent study by the University of Minnesota's David Jacobs shows that eating whole grains confers an even greater risk-reduction in mortality from inflammatory diseases. Jacobs and his colleagues followed more than 27,000 post-menopausal women for 17 years and concluded that "oxidative stress reduction by constituents of whole grain is a likely mechanism for the protective effect."
American Journal of Clinical Nutrition, June 2007; vol 85(6):1606-1614

More Cereal Fiber associated with less diabetes risk

A team of German researchers led by Matthias Schulze followed over 16,000 adults for a period of seven years and found that those who ate the most cereal fiber had a 27% lower risk of developing diabetes than those who ate the least. No link was noted with total fiber – just with cereal fiber.
Archives of Internal Medicine, May 2007; 14; 167(9):956-65

Whole Grains May Reduce Colorectal Cancer Risk

A team of researchers led by Arthur Schatzkin studied data for almost half a million middle-aged men and women enrolled in the NIH-AARP Diet and Healthy Study, to learn whether fiber intake and/or whole grains might reduce the risk of colorectal cancer. In this analysis, total dietary fiber intake was not associated with a reduced risk of colorectal cancer, but both grain fiber and whole grains were shown likely to reduce the risk of colorectal cancer.
American Journal of Clinical Nutrition, May 2007; vol 85(5):1353-1360

Better Blood Sugar Control with Certain Whole Grains

Swedish researchers at Lund University have determined that certain whole grain products can help control blood sugar for up to ten hours. A team led by Anne Nilsson tested four types of grain, and found that barley had the strongest effect, but that wholegrains in bread controlled blood sugar better than grains in boiled porridge.
European Journal of Clinical Nutrition, May 23, 2007

Study Confirms Heart Benefits of Whole Grains

Eating an average of 2.5 servings of whole grain foods each day can lower your risk of cardiovascular disease by almost one-quarter. That's the finding of a seven-study meta-analysis of 285,000 men and women led by Philip Mellen of Wake Forest University. In light of this evidence, Mellen said, policy-makers, scientists and clinicians should "redouble efforts" to get people to eat more whole grains.
Nutrition, Metabolism & Cardiovascular Diseases, April 2007 online

Breast Cancer: Cereal Fiber May Affect Estrogen Regulation

A UK study suggests that women who eat large amounts of fiber could cut breast cancer risk in half. The effect was greatest on pre-menopausal women, which Janet Cade and her team at Leeds University say may be because fiber affects the way the body processes and regulates the female hormone estrogen.
International Journal of Epidemiology, April 2007; 36(2):431-8

Whole Grains Associated with Lower BMI

A study of 150 college students found that higher whole grain intake was associated with lower BMI (Body Mass Index). Overall, students averaged only 0.7 servings per day of whole grain, and authors, led by Nick Rose, noted that low availability of whole grains on and around campus could be responsible for low intake.
Journal of Nutrition and Education Behavior, March 2007; vol 39 (2); 90-94

High Fiber Diet cuts Inflammation Levels

C-reactive protein (CRP), a known marker for inflammation, is increasingly accepted as a good predictor of both type 2 diabetes and cardiovascular disease. A high-fiber diet – whether from foods like whole grains, fruits and vegetables or from fiber supplements – can cut CRP levels up to 40%. Ironically, the effect was more pronounced in healthy lean people than in obese ones, according to lead researcher Dana King at the Medical University of South Carolina.
Archives of Internal Medicine, March 2007; 12; 167(5):502-6

Whole Grains Cut Children's Asthma Risk in Half

A team from the Dutch National Institute of Public Health and the Environment found that children who ate whole grains were 54% less likely to develop asthma and 45% less likely to develop wheezing than children who did not eat whole grains.
Thorax, December 2006; 61(12):1048-53

Whole Grains May Help Reduce Blood Pressure

USDA researcher Kay Behall and colleagues studied a small group of men and women as they followed a 10-week diet where all the grains were whole grains. The subjects, all of whom had slightly elevated cholesterol, showed significant reductions in both systolic and diastolic blood pressure when whole grains were added. They also lost about 1kg during the course of the study– although the whole grain diet was higher in calories than a control low-fat diet with refined grains used at the start of the study.
Journal of the American Dietetic Association, September 2006; vol 106(9):1445-9

Whole Grains Reduce Weight, Improve Nutrition

Researchers at the University of Rhode Island, in a six-month study headed up by Kathleen Melanson, found that whole grain cereals helped 180 overweight adults lose weight while increasing their consumption of fiber, magnesium and vitamin B-6.
Journal of the American Dietetic Association, September 2006; vol 106(9):1380-8

Gum Disease Risk Reduced with Whole Grains

The risk of periodontitis, a serious inflammation of the gums that is the major cause of tooth loss in adults, may be reduced by eating more whole grains. Anwar Merchant and colleagues at McMaster University in Ontario studied more than 34,000 men over a 14-year period, and concluded that three to four servings of whole grains daily "may be optimal to reduce periodontitis risk."
American Journal of Clinical Nutrition, June 2006; vol 83(6):1395-1400

Whole Grains Cut Triglycerides

Nancy Keim and a team at the USDA ARS Western Human Nutrition Center studied 10 women age 20-45 who ate a whole grain diet for three days, then ate the same foods but with refined grains in place of whole grains. Blood samples at the end of each 3-day period showed that the refined grains diet caused a significant increase in triglycerides and a worrisome protein called "apolipoprotein CIII" (apoCIII), both of which have been associated with increased risk of heart disease. A larger study is underway.
Agricultural Research, March 2006, 20-21

Whole Grains Lower Diabetes, Heart Risk

A joint Danish-American study analyzed diet records and took blood samples from 938 healthy men and women. The team, including Majken Jensen of Aarhus University Hospital and the Harvard School of Public Health, found that those with the highest whole grain consumption had the lowest levels of risk factors in their blood: homocysteine 17% lower, insulin and C-peptide both 14% lower, and leptin 11% lower. Researchers concluded, "The results suggest a lower risk of diabetes and heart disease in persons who consume diets high in whole grains."
American Journal of Clinical Nutrition, February 2006; vol 83(2):275-283

Children Benefit Quickly from Healthy Diet

Overweight children, age 9-15, spent two weeks on an all-you-can-eat diet of whole grains, fruits, vegetables and lean protein, while exercising 2.5 hours each day. UCLA researchers led by Dr. James Barnard reported that in just two weeks the children's cholesterol levels dropped an average of 21%, while insulin levels fell 30%. Leptin, a hormone thought to be connected to appetite, decreased on average 57%.
Study presented at American Heart Association conference, March 2006

Whole Grains Reduce Elderly Mortality

While many studies have previously shown that whole grains reduce the risk of metabolic syndrome in middle-aged adults, a recent study led by Nadine Sahyoun at the University of Maryland shows for the first time that this benefit extends to older adults. In Sahyoun's study, whole grains were also linked with a lower overall risk of mortality from cardiovascular disease.
American Journal of Clinical Nutrition, January 2006; vol 83(1):124-133

Whole Grains Slow Buildup of Plaque

Following up on studies that show a relationship between whole grain consumption and heart health, researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, led by Alice Lichtenstein, have found one reason why. Over 3 years, they studied the diet habits and artery-diameter measurements of 229 post-menopausal women already diagnosed with a heart condition, and found that eating 6 servings or more per week of whole grains was associated with slower buildup of artery-narrowing plaque.
American Heart Journal, July 2005; vol 150(1):94-101

Whole Grains Help Your Heart

Yet another study documents the relationship between whole grain consumption and heart health. Dr. Majken Jensen and fellow professionals at the Harvard School of Public Health analyzed diet and health records of over 27,000 men aged 40-75, over a period of 14 years, and found that those with the highest whole grain intake (about 40g per day) cut heart disease risk by almost 20% – but even those eating just 25g cut their CHD risk by 15%.
American Journal of Clinical Nutrition, December 2004; vol 80:1492-1499

Whole Grains High In Antioxidants

Dr. Rui Hai Liu of Cornell and his colleagues discovered that whole grains contain protective antioxidants in quantities rivalling or exceeding those in fruits and vegetables. Corn, for instance, has almost twice the antioxidant activity of apples, while wheat and oats almost equal broccoli and spinach in antioxidant activity.
American Institute for Cancer Research (AICR) International Conference on Food, Nutrition and Cancer, November 2004

Whole Grains Help You Weigh Less

A team led by Dr. Pauline Koh-Banerjee studied diet and health records of 72,000 men and found that those who ate 40 grams of whole grains per day cut middle-age weight gain by up to 3.5 pounds. Just one cup of cooked oatmeal or two slices of whole-wheat bread would provide this amount of whole grain.
American Journal of Clinical Nutrition, November 2004; vol 80(5):1237-45

Whole Grains Reduce Diabetes Risk

Dr. Nicola McKeown and fellow researchers at Tufts University found that people who eat three or more servings of whole grains a day, especially from high-fiber cereals, are less likely to develop insulin resistance and metabolic syndrome, common precursors of both Type 2 diabetes and cardiovascular disease.
Diabetes Care, February 2004; vol 27:538-546

Whole Grains Cut Heart Disease Risk

Researchers led by Dr. Mark Pereira collected data on 91,058 men and 245,186 women who participated in 10 studies in the US and Europe. After 6-10 years of followup, the research showed that, for each 10 grams of fiber consumed per day, there was a 14% reduction in heart disease risk and a 25% reduction in risk of dying from heart disease. In short, the cereal fiber in whole grains appears to make heart disease much less likely—and less serious if it does occur.
Archives of Internal Medicine, February 2004; vol 164:370-376

Whole Grains Lower Obesity Risk

As part of the well-known Nurses' Study, Simin Liu and fellow researchers at the Harvard School of Public Health followed over 74,000 women from 1984-1996, and concluded that women who consumed more whole grains consistently weighed less than women who consumed less whole grains.
American Journal of Clinical Nutrition, November 2003; vol 78:5/920-927

Whole Grains Lessen Rectal Cancer Risk

At the University of Utah, a team led by Dr. Martha Slattery found that high intakes of vegetables, fruits and whole grains reduced the risk of rectal cancer by 28%, 27% and 31% respectively. A high-fiber diet (more than 34 grams of fiber per day) reduced rectal cancer by an impressive 66%, in this study of over 2000 people.
American Journal of Clinical Nutrition, February 2004; vol 79:2/274-281