Few Patients with Suspected Non-celiac Gluten Sensitivity Actually Show Gluten-Specific Symptoms

Many patients who respond well to a gluten free diet, but don’t test positive for celiac disease, are thought to have non-celiac gluten sensitivity. However, a closer look at this population is raising some doubts. Researchers in Spain analyzed data from 10 studies comprising 1312 adults, all of which were double blind, placebo controlled gluten challenges (meaning that neither the researchers nor the participants knew if they were getting a gluten-free diet or the gluten-containing placebo).  Only 16% of the non-celiac gluten sensitivity patients showed gluten-specific symptoms when exposed to the gluten-containing diet, and 40% of them had similar or increased symptoms when on the gluten-free control diet. The researchers conclude that these results “cast doubt on gluten as the culprit food component in most patients with presumptive [non-celiac gluten sensitivity].”  
Perspectives in Clinical Gastroenterology and Hepatology. 2017 Mar:15(3):339-348. (Molina-Infante J et al.)