Rye

While fruits and vegetables are known as sources of healthy antioxidants and phenolic compounds, research increasingly shows that whole grains contain them too. In this review, researchers analyzed the total phenolic contents, phenolic acid profile and antioxidant activity of several whole grains, including wheat, corn, rice, barley, sorghum, rye, oat and millet. The review shows that whole grains contain a number of phytochemicals (including antioxidants) and significantly exhibit antioxidant activity. Researchers conclude that the consumption of whole grains is considered to have significant health benefits including prevention of chronic diseases such as cardiovascular disease, diabetes, and cancer because of the contribution of phenolic compounds. 
Critical Reviews in Food Science and Nutrition. 2014 July 30. [epub ahead of print] (Van Hung P et al.)

Wondering what to have for breakfast? Researchers in Sweden, where rye has been the go-to grain for centuries, set out to compare two breakfast bread choices: whole grain rye crisp bread and (refined) white wheat bread. Although subjects ate similar amounts of each food for breakfast, they reported higher fullness, lower hunger, and less desire to eat after consuming the rye crisp than after eating the white bread. When study participants were allowed to eat as much as they wanted at lunch later that day, those who ate rye crisp for breakfast ate about 8% fewer calories at lunch.
Nutrition Journal. 2014 Mar 25;13(1):26. (Forsberg et al.)

Scientists at the Danish Cancer Society Research Center collaborated on a study to investigate the link between whole grain intake and colorectal cancer. Rather than rely on whole grain intake estimation, they measured levels of alkylresorcinols, which are biomarkers of whole grain rye and wheat intake, in 1372 colorectal cancer patients and an equal number of controls. They found that those with the highest whole grain intake had the lowest risk of distal colon cancer, but did not find a correlation with colon cancer overall, with proximal colon cancer or with rectal cancer.
Journal of the National Cancer Institute. 2013 Dec 7 [Epub ahead of print] (Kyrø et al.) 

To explore differences within the universe of whole grain food options, scientists at Aarhus University in Denmark conducted a randomized cross-over study involving 15 subjects with metabolic syndrome. The subjects sample four kinds of bread: rye bread made with intact kernels, whole wheat bread, whole wheat bread with concentrated arabinoxylan, or whole wheat bread with beta-glucan. The rye kernel bread scored highest on a variety of measures, while the beta-glucan sample also scored well.
European Journal of Clinical Nutrition. 2013 Nov 20 [Epub ahead of print] (Hartvigsen et al.)

Epidemiological studies suggest a relationship between whole grain intake and insulin sensitivity. In an effort to investigate this possible relationship a randomized controlled trial was conducted by a group of European scientists. One hundred and forty six individuals were recruited in two European cities (Kuopio, Finland and Naples, Italy) and randomized into two groups. One group consumed a diet based on refined grains and the second group was given a diet based on whole grains. After a 12-week period where good adherence was achieved, there was no significant difference in insulin sensitivity measures between the two groups. 
Clinical Nutrition. 2013. [Epub February 8, 2013] (Giacco et al.)

Twenty-four healthy subjects in Sweden were randomly assigned to eat either a breakfast of rye porridge or the same amount of calories in the form of refined wheat bread for three weeks. After a wash-out period of 3-4 weeks, they switched to the other breakfast choice. At three points during each three-week diet, researchers recorded appetite ratings (hunger, satiety, and desire to eat) for 24 hours. They found that the whole grain rye porridge resulted in higher satiety, less hunger, and less desire to eat for four hours after breakfast, but that the differences did not extend into the afternoon. The satiety effect persisted throughout the three weeks of the diet.
Physiology & Behavior, 28 October 2011 [Epub ahead of print] (Isaksson et al.)

Documenting the benefits of whole grains often depends on asking people to recall how often they eat whole grain foods, a process subject to less-than-precise memories and lack of understanding of just what constitutes a whole grain food. Now scientists at Uppsala University in Sweden have provided further evidence that blood levels of alkylresorcinols – a type of fat found in the bran of rye and wheat but in few other foods — can serve as more objective evidence of regular consumption of wheat and rye.  The researchers asked 72 adults to keep detailed, weighed records of everything they ate for 3 days, on two separate occasions, then tested the levels of alkylresorcinols in their blood. They found a very reliable relationship between the foods eaten and the blood levels measured.
The Journal of Nutrition, September 1, 2011. [Epub ahead of print July 2011]

Researchers at the Swedish University of Agricultural Sciences carried out two cross-over studies in which subjects were asked to rate their hunger, satiety, and desire to eat during an eight-hour period following consumption of various isocaloric grain foods at breakfast.  All forms of whole rye – rye bread with milled or whole kernels, and milled rye porridge – provided greater satiety than the control refined wheat bread, but the unmilled kernels held hunger at bay the longest.
Nutrition Journal, April 11, 2011; 10:31

Researchers in Scandinavia are increasingly studying associations between good health and the traditional Nordic diet — characterized by fish, cabbages, rye bread, oatmeal, apples and pears, and root vegetables. As might be expected, an overall healthy Nordic diet did reduce mortality. And when the different components were evaluated separately, whole grain rye bread was most strongly associated with reduced mortality in men.
The Journal of Nutrition, April 1, 2011; 141(4):639-44